Ketoprofen 100mg/mL in a clear, yellow solution for injection.
 
Action:
Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) of the propionic acid class. Ketoprofen inhibits the cyclooxygenase pathway of the arachidonic acid cascade. Cyclooxygenase is the major enzyme involved in the conversion of arachidonic acid to the vasoactive prostaglandins, prostacyclin and thromboxane. The anti-inflammatory, analgesic and antipyretic effects of ketoprofen are thus attributable to its inhibition of cyclooxygenase.
 
Indication:
HORSES: Anti-inflammatory and analgesic treatment of musculoskeletal disorders, including: lameness of traumatic origin, arthroses, arthritis, osteitis, spavin, navicular disease, tendonitis, bursitis, laminitis, myositis and post-surgical inflammation. Symptomatic analgesic treatment in colic, alone or associated with the treatment of the primary cause. Symptomatic treatment of fever.
CATTLE: Anti-inflammatory, analgesic and antipyretic treatment of respiratory disorders, acute mastitis, mammary oedema, colic and musculoskeletal disorders.
 
Contraindication: 
Do not administer to animals with kidney failure. Do not administer where these is evidence of a haemorrhagic disorder. Do not administer intra-arterially. Do not administer to animals that have developed hypersensitivity to ketoprofen. Do not use concurrently with other non-steroidal anti-inflammatory drugs, diuretics or anticoagulants. Do not mix with another substance in the same syringe. Do not use in pregnant mares or in foals less than 15 days of age, as data have not been reported to establish the safety of use in these animals.
 
DOSAGE: 
HORSES: Administer by i/v injection. Dose 2.2mg ketoprofen/kg, 1mL/45kg b.w.For musculoskeletal disorders, dose once a day for 3–5 days. For colic, a single injection is usually sufficient. Repeat, if necessary, after clinical reassessment.
CATTLE: Administer by the i/v or i/m route in the neck. Intravenous injection is preferred for the initial dose. Dose 3.0mg ketoprofen/kg, 3mL/100kg b.w, for 1–3 consecutive days.
 
Special Precautions:
If used in performance horses, observe the regulations of the relevant authorities regarding medication.
 
Withholding Times:
MILK: Nil.
Meat: Horses & Cattle after IV: Animals producing meat or offal for human consumption must not be sold for slaughter either during treatment or within 4 days of the last treatment. Meat: Cattle after IM: Animals producing meat or offal for human consumption must not be sold for slaughter either during treatment or within 2 days of the last treatment
 
Human First Aid, Symptoms Of Poisoning:
If swallowed, DO NOT induce vomiting. For advice, contact the National Poisons Centre (0800 POISON or 0800 764 766) or a doctor. If skin or hair contact occurs, remove contaminated clothing and flush skin and hair with running water.
 
Other Information:
Protect from light.
Once vial is broached, use contents within 28 days or discard.
Safety Data Sheet available upon request